The TEX14 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TEX14. This antibody recognizes Human antigen. The TEX14 Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Function: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).
Post Translational Modifications: Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.
Subcellular Location: Cytoplasm. Midbody. Chromosome>Centromere>Kinetochore. Note: Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.
Tissue Specificity: Expression restricted to testis.
Subunit Structure: Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101 (By similarity).
Similarity: The protein kinase domain is predicted to be catalytically inactive.The GPPX3Y motif mediates interaction with CEP55.Belongs to the protein kinase superfamily